GUIDELINE PROPOSAL FOR PHARMA COMPANIES TO MANAGE PHARMACOVIGILANCE ACTIVITIES IN DIGITAL MEDIA




Mutability and importance of a hypermutable cell subpopulation that produces stress-induced mutants in Escherichia coli.

In bacterial, yeast, and human cells, stress-induced mutation mechanisms are induced in growth-limiting environments and produce non-adaptive and adaptive mutations.These mechanisms may accelerate evolution specifically when cells are maladapted to their environments, i.e., when they are are stressed.One mechanism of stress-induced mutagenesis in E

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